Advancement of Lung Cancer Diagnosis with Transfer Learning: Insights from VGG16 Implementation

Abstract

Lung cancer continues to be one of the leading causes of cancer-related mortality globally, largely due to the challenges associated with its early and accurate detection. Timely diagnosis is critical for improving survival rates, and advances in artificial intelligence (AI), particularly deep learning, are proving to be valuable tools in this area. This study introduces an enhanced deep learning-based approach for lung cancer classification using the VGG16 neural network architecture. While previous research has demonstrated the effectiveness of ResNet-50 in this domain, the proposed method leverages the strengths of VGG16 particularly its deep architecture and robust feature extraction capabilities to improve diagnostic performance. To address the limitations posed by scarce labelled medical imaging data, the model incorporates transfer learning and fine-tuning techniques. It was trained and validated on a well-curated dataset of lung CT images. The VGG16 model achieved a high training accuracy of 99.09% and a strong validation accuracy of 95.41%, indicating its ability to generalize well across diverse image samples. These results reflect the model’s capacity to capture intricate patterns and subtle features within medical imagery, which are often critical for accurate disease classification. A comparative evaluation between VGG16 and ResNet-50 reveals that VGG16 outperforms its predecessor in terms of both accuracy and reliability. The improved performance underscores the potential of the proposed approach as a reliable and scalable AI-driven diagnostic solution. Overall, this research highlights the growing role of deep learning in enhancing clinical decision-making, offering a promising path toward earlier detection of lung cancer and ultimately contributing to better patient outcomes.

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References

National Lung Screening Trial Research Team. Reduced lung-cancer mortality with low-dose computed tomographic screening. New England Journal of Medicine. 2011;365(5):395–409. doi: 10.1056/NEJMoa1102873

Siegel RL, Miller KD, Jemal A. Cancer statistics, 2020. CA: A Cancer Journal for Clinicians. 2020;70(1):7–30. doi: 10.3322/caac.21590SCIRP+1ACS Journals+1

Horeweg N, van Rosmalen J, Heuvelmans MA, et al. Lung cancer probability in patients with CT-detected pulmonary nodules: a prespecified analysis of data from the NELSON trial. The Lancet Oncology. 2014;15(12):1332–1341. doi: 10.1016/S1470-2045(14)70389-4

American Cancer Society. Cancer Facts & Figures 2020. Atlanta: American Cancer Society; 2020.

Han D, Heuvelmans MA, Vliegenthart R, et al. CT-based risk estimation for indeterminate pulmonary nodules: the PanCan model versus the Brock model. European Radiology. 2015;25(10):2987–2996. doi: 10.1007/s00330-015-3700-0

van Ginneken B, Armato SG 3rd, de Hoop B, et al. Computer-aided diagnosis: how to move from the laboratory to the clinic. Radiology. 2011;261(3):719–732. doi: 10.1148/radiol.11110569

Litjens G, Kooi T, Bejnordi BE, et al. A survey on deep learning in medical image analysis. Medical Image Analysis. 2017;42:60–88. doi: 10.1016/j.media.2017.07.005

Armato SG 3rd, McLennan G, Bidaut L, et al. The Lung Image Database Consortium (LIDC) and Image Database Resource Initiative (IDRI): a completed reference database of lung nodules on CT scans. Medical Physics. 2011;38(2):915–931. doi: 10.1118/1.3528204

Setio AAA, Traverso A, de Bel T, et al. Validation, comparison, and combination of algorithms for automatic detection of pulmonary nodules in computed tomography images: the LUNA16 challenge. Medical Image Analysis. 2017;42:1–13. doi: 10.1016/j.media.2017.06.015

Kumar D, Wong A, Clausi DA. Lung nodule classification using deep features in CT images. In: 2015 12th Conference on Computer and Robot Vision. IEEE; 2015:133–138. doi: 10.1109/CRV.2015.25

Shen W, Zhou M, Yang F, et al. Multi-scale convolutional neural networks for lung nodule classification. In: International Conference on Information Processing in Medical Imaging. Springer; 2015:588–599. doi: 10.1007/978-3-319-19992-4_46

Anthimopoulos M, Christodoulidis S, Ebner L, Christe A, Mougiakakou S. Lung pattern classification for interstitial lung diseases using a deep convolutional neural network. IEEE Transactions on Medical Imaging. 2016;35(5):1207–1216. doi: 10.1109/TMI.2016.2535865

Krizhevsky A, Sutskever I, Hinton GE. ImageNet classification with deep convolutional neural networks. Communications of the ACM. 2017;60(6):84–90. doi: 10.1145/3065386

Simonyan K, Zisserman A. Very deep convolutional networks for large-scale image recognition. arXiv preprint arXiv:1409.1556. 2014.

He K, Zhang X, Ren S, Sun J. Deep residual learning for image recognition. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition. 2016:770–778. doi: 10.1109/CVPR.2016.90

Szegedy C, Liu W, Jia Y, et al. Going deeper with convolutions. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition. 2015:1–9. doi: 10.1109/CVPR.2015.7298594

Huang G, Liu Z, Van Der Maaten L, Weinberger KQ. Densely connected convolutional networks. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition. 2017:4700–4708. doi: 10.1109/CVPR.2017.243

Tan M, Le Q. EfficientNet: rethinking model scaling for convolutional neural networks. In: International Conference on Machine Learning. PMLR; 2019:6105–6114.

Rajpurkar P, Irvin J, Zhu K, et al. CheXNet: radiologist-level pneumonia detection on chest x-rays with deep learning. arXiv preprint arXiv:1711.05225. 2017.

Shin HC, Roth HR, Gao M, et al. Deep convolutional neural networks for computer-aided detection: CNN architectures, dataset characteristics and transfer learning. IEEE Transactions on Medical Imaging. 2016;35(5):1285–1298. doi: 10.1109/TMI.2016.2528162

Lakhani P, Sundaram B. Deep learning at chest radiography: automated classification of pulmonary tuberculosis by using convolutional neural networks. Radiology. 2017;284(2):574–582. doi: 10.1148/radiol.2017162326

Tajbakhsh N, Shin JY, Gurudu SR, et al. Convolutional neural networks for medical image analysis: full training or fine tuning? IEEE Transactions on Medical Imaging. 2016;35(5):1299–1312. doi: 10.1109/TMI.2016.2535302

Li Q, Cai W, Wang X, et al. Medical image classification with convolutional neural network. In: 2014 13th International Conference on Control Automation Robotics & Vision (ICARCV). IEEE; 2014:844–848. doi: 10.1109/ICARCV.2014.7064414

Shin HC, Roth HR, Gao M, et al. Deep convolutional neural networks for computer-aided detection: CNN architectures, dataset characteristics and transfer learning. IEEE Transactions on Medical Imaging. 2016;35(5):1285–1298. doi: 10.1109/TMI.2016.2528162

LeCun Y, Bengio Y, Hinton G. Deep learning. Nature. 2015;521(7553):436-444.

DOI: 10.1038/nature14539

Dhillon A, Verma GK. Convolutional neural network: a review of models, methodologies and applications to object detection. Prog Artif Intell. 2020;9:85–112.

DOI: 10.1007/s13748-019-00192-2

Alsharif MH, Yadav A, Alohali Y, Albreem MA. Lung cancer detection using deep learning neural network and CT scan images. In: 2020 IEEE 6th World Forum on Internet of Things (WF-IoT). IEEE; 2020:1-5.

DOI: 10.1109/WF-IoT48130.2020.9221240

Ardila D, Kiraly AP, Bharadwaj S, et al. End-to-end lung cancer screening with three-dimensional deep learning on low-dose chest computed tomography. Nat Med. 2019;25(6):954-961.

DOI: 10.1038/s41591-019-0447-x

Kermany DS, Goldbaum M, Cai W, et al. Identifying medical diagnoses and treatable diseases by image-based deep learning. Cell. 2018;172(5):1122-1131.e9.

DOI: 10.1016/j.cell.2018.02.010

Kaur T, Gandhi TK. Automated brain image classification based on VGG-16 and transfer learning. In: 2019 3rd International Conference on Trends in Electronics and Informatics (ICOEI). IEEE; 2019:230-235.

DOI: 10.1109/ICOEI.2019.8862716

Yosinski J, Clune J, Bengio Y, Lipson H. How transferable are features in deep neural networks? In: Advances in Neural Information Processing Systems. 2014;27.

DOI: (N/A, conference proceedings, available online: https://arxiv.org/abs/1411.1792)

Xie Y, Zhang J, Xia Y, Fulham M, Zhang S. Knowledge-based collaborative deep learning for benign-malignant lung nodule classification on chest CT. IEEE Transactions on Medical Imaging. 2019;38(4):991–1004.

DOI: 10.1109/TMI.2018.2874821

Liao F, Liang M, Li Z, Hu X, Song S. Evaluate the malignancy of pulmonary nodules using the 3D deep leaky noisy-or network. In: International Conference on Medical Image Computing and Computer-Assisted Intervention. Springer; 2019:432-440.

DOI: 10.1007/978-3-030-32251-9_49

Chen H, Zhang Y, Zhang W, et al. Low-dose CT denoising with generative adversarial network. IEEE Transactions on Medical Imaging. 2018;37(6):1348–1357.

DOI: 10.1109/TMI.2017.2779199

Tang Z, Zhang H, Lu L, et al. Lung cancer diagnosis with deep learning in CT images: a review. IEEE Reviews in Biomedical Engineering. 2020;13:309–320.

DOI: 10.1109/RBME.2020.2995385

González et al. (2018): Disease staging and prognosis in smokers using deep learning in chest computed tomography. American Journal of Respiratory and Critical Care Medicine, 197(2), 193–203. DOI: 10.1164/rccm.201705-0860OC

Zreik et al. (2018): Deep learning analysis of the myocardium in coronary CT angiography for identification of patients with functionally significant coronary artery stenosis. Medical Image Analysis, 44, 72–85. DOI: 10.1016/j.media.2017.11.008

Anthimopoulos et al. (2018): Semantic segmentation of pathological lung tissue with dilated fully convolutional networks. IEEE Journal of Biomedical and Health Informatics, 23(2), 714–722. DOI: 10.1109/JBHI.2018.2818620

Ouyang et al. (2019): Learning dual-task residual attention networks for pulmonary lesion segmentation and classification. Medical Image Analysis, 63, 101715. DOI: 10.1016/j.media.2019.101715

Tan & Le (2021): EfficientNetV2: Smaller models and faster training. In Proceedings of the 38th International Conference on Machine Learning (Vol. 139, pp. 10096–10106). PMLR. DOI: 10.48550/arXiv.2104.00298

Ronneberger et al. (2015): U-Net: Convolutional networks for biomedical image segmentation. In Medical Image Computing and Computer-Assisted Intervention – MICCAI 2015 (Vol. 9349, pp. 234–241). Springer. DOI: 10.1007/978-3-319-24574-4_28

Published
2025-06-01
How to Cite
[1]
V. Lakide and V. Ganesan, “Advancement of Lung Cancer Diagnosis with Transfer Learning: Insights from VGG16 Implementation ”, j.electron.electromedical.eng.med.inform, vol. 7, no. 3, pp. 729-739, Jun. 2025.
Section
Medical Engineering